Search results for "Compostos de nitrogen"

showing 2 items of 2 documents

Nitroenynes as Electrophiles in Organocatalysis and their Application in the Synthesis of Chiral Heterocycles

2021

Nitroenynes are an interesting electrophile in asymmetric organocatalysis, due to the versatility of the functional groups present in its structure. This review covers the organocatalytic examples using this electrophile and its application for the synthesis of chiral heterocycles.

Compostos de nitrogenCatàlisiChemistryOrganocatalysisOrganic ChemistryElectrophilePhysical and Theoretical ChemistryQuímica orgànicaCombinatorial chemistryEuropean Journal of Organic Chemistry
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Recent Advances in Catalytic Enantioselective Synthesis of Pyrazolones with a Tetrasubstituted Stereogenic Center at the 4-Position

2020

AbstractPyrazolone [2,4-dihydro-3H-pyrazol-4-one] represents one of the most important five-membered nitrogen heterocycles which is present in numerous pharmaceutical drugs and molecules with biological activity. Recently, many catalytic methodologies for the asymmetric synthesis of chiral pyrazolones have been established with great success, specially, for the synthesis of pyrazolones bearing a tetrasubstituted stereocenter at C-4. This review summarizes these excellent research studies since 2018, including representative examples and some mechanistic pathways explaining the observed stereochemistry.1 Introduction2 Catalytic Enantioselective Synthesis of Chiral Pyrazolones with a Full Car…

Compostos heterocíclicsChemistryOrganic ChemistryHeteroatomPyrazoloneEnantioselective synthesisCombinatorial chemistryCatalysisStereocenterCatalysisCompostos de nitrogenCatàlisiOrganocatalysismedicineResearch studiesPyrazolonesmedicine.drug
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